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感染艾滋病毒患者的恶性肿瘤

Malignant tumours in patients with HIV infection.

作者信息

Tirelli U, Franceschi S, Carbone A

机构信息

Centro Regionale di Riferimento Oncologico, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Aviano, Italy.

出版信息

BMJ. 1994 Apr 30;308(6937):1148-53. doi: 10.1136/bmj.308.6937.1148.

DOI:10.1136/bmj.308.6937.1148
PMID:8173459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2540158/
Abstract

One of the most important though somewhat neglected aspects of research in HIV infection concerns the development, clinicopathological characteristics, and treatment of malignant tumours in infected patients. With the improved survival of patients with AIDS owing to the better prevention and treatment of infectious complications there may well be an increase in AIDS related malignancies. This paper reviews the epidemiology, pathology, and treatment of malignant tumours in patients with HIV.

摘要

在HIV感染研究中，尽管有些方面被忽视，但其中最重要的一个方面涉及受感染患者恶性肿瘤的发生、临床病理特征及治疗。由于对感染并发症的预防和治疗有所改善，艾滋病患者的生存率有所提高，与艾滋病相关的恶性肿瘤很可能会增加。本文综述了HIV患者恶性肿瘤的流行病学、病理学及治疗情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/5bb8286daee0/bmj00438-0049-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/a5c9c1b60c42/bmj00438-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/0d1e26b68dd7/bmj00438-0047-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/fb142420a2a9/bmj00438-0047-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/538667b26bd2/bmj00438-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/7c4d81027c09/bmj00438-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/a5a2ec64b5df/bmj00438-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/c67e87de11e7/bmj00438-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/e012d429161c/bmj00438-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/5bb8286daee0/bmj00438-0049-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/a5c9c1b60c42/bmj00438-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/0d1e26b68dd7/bmj00438-0047-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/fb142420a2a9/bmj00438-0047-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/538667b26bd2/bmj00438-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/7c4d81027c09/bmj00438-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/a5a2ec64b5df/bmj00438-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/c67e87de11e7/bmj00438-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/e012d429161c/bmj00438-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87a/2540158/5bb8286daee0/bmj00438-0049-c.jpg

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Hodgkin disease and HIV.霍奇金淋巴瘤与人类免疫缺陷病毒
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根据爱泼斯坦-巴尔病毒潜伏基因表达情况，人类免疫缺陷病毒相关的系统性淋巴瘤可分为两大主要类型。
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High incidence of monoclonal EBV episomes in Hodgkin's disease and anaplastic large-cell KI-1-positive lymphomas in HIV-1-positive patients.在HIV-1阳性患者的霍奇金淋巴瘤和间变性大细胞KI-1阳性淋巴瘤中，单克隆EBV附加体的高发生率。
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Demonstration of Epstein-Barr viral genomes by in situ hybridization in acquired immune deficiency syndrome-related high grade and anaplastic large cell CD30+ lymphomas.通过原位杂交技术在获得性免疫缺陷综合征相关的高级别及间变性大细胞CD30+淋巴瘤中检测爱泼斯坦-巴尔病毒基因组
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Demonstration of a unique Epstein-Barr virus-positive cellular clone in metachronous multiple localizations of Hodgkin's disease.在霍奇金淋巴瘤的异时性多部位病变中发现独特的爱泼斯坦-巴尔病毒阳性细胞克隆。
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