Hollinger M A, Killam K F, Deneau G A
Psychopharmacol Commun. 1975;1(3):319-25.
Most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). We now report data obtained from the monkey (Macaca mulatta). In vivo incorporation of [U-14C]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. Exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into protein of 16 discrete brain areas.
大多数关于阿片类药物耐受动物脑蛋白合成的研究都局限于啮齿类动物（大鼠、小鼠和兔子）。我们现在报告从恒河猴（猕猴）获得的数据。研究了正常和阿片类药物耐受的灵长类动物脑不同区域中[U-14C]赖氨酸在体内掺入酸沉淀蛋白的情况。给动物注射放射性氨基酸1小时脉冲后，16个离散脑区蛋白的掺入率没有显著差异。
