McKay C, Beastall G H, Imrie C W, Baxter J N
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Br J Surg. 1994 Mar;81(3):357-60. doi: 10.1002/bjs.1800810311.
Serum levels of parathyroid hormone (PTH), calcium and albumin were measured daily for 5 days in 41 selected patients with moderate to severe acute pancreatitis. The PTH level was measured by means of a two-site immunoradiometric assay specific for the intact polypeptide. A rise in PTH level was observed more commonly in patients with a complicated or fatal outcome than in those with an uncomplicated course (14 of 16 versus six of 25 patients, P < 0.001). Although PTH levels were variable in the presence of hypocalcaemia, raised concentrations were found more frequently in patients with complications (seven of eight versus two of seven without complications, P = 0.035). This study confirms that an appropriate rise in PTH level occurs in response to the hypocalcaemic stimulus in patients with acute pancreatitis.
在41例中重度急性胰腺炎患者中，连续5天每天测量血清甲状旁腺激素（PTH）、钙和白蛋白水平。采用针对完整多肽的双位点免疫放射分析法定量检测PTH水平。与病情未复杂化的患者相比，伴有复杂或致命结局的患者中PTH水平升高更为常见（16例中有14例，25例中6例，P<0.001）。尽管在低钙血症情况下PTH水平存在差异，但并发症患者中PTH浓度升高更为常见（8例中有7例，无并发症的7例中有2例，P=0.035）。本研究证实，急性胰腺炎患者会因低钙血症刺激而出现PTH水平的适当升高。
