Corpet D E, Pirot V, Goubet I
Laboratoire des Xénobiotiques, et Ecole Nationale Vétérinaire, Institut National de la Recherche Agronomique, Toulouse, France.
Cancer Lett. 1993 Nov 1;74(3):183-7. doi: 10.1016/0304-3835(93)90241-z.
The carcinogenicity of asbestos to the gut is controversial. The aberrant crypt focus (ACF) assay is proposed as a test for colon carcinogens. We have scored ACF in the colon of rats and mice, one month after per os gavages with suspensions of asbestos fibers. Crocidolite asbestos induced ACF in the colon of rats in two independent experiments (P = 0.02 and P < 0.01 compared to controls given water), and was ten times less effective than the carcinogen azoxymethane. Chrysotile asbestos also induced ACF in rats. Neither crocidolite nor chrysotile induced ACF in mice. The data suggest that ingested asbestos may be carcinogenic to the colon.
石棉对肠道的致癌性存在争议。异常隐窝灶（ACF）检测被提议作为一种结肠癌致癌物检测方法。我们在用石棉纤维悬浮液经口灌胃大鼠和小鼠一个月后，对其结肠中的ACF进行了评分。在两项独立实验中，青石棉在大鼠结肠中诱导产生了ACF（与给予水的对照组相比，P = 0.02和P < 0.01），且其效力比致癌物偶氮甲烷低十倍。温石棉在大鼠中也诱导产生了ACF。青石棉和温石棉在小鼠中均未诱导产生ACF。这些数据表明，摄入的石棉可能对结肠具有致癌性。
