Angelini A, Imparato L, Landi C, Porfido F A, Ciarimboli M, Marro A
Loreto Crispi Hospital USL No. 37, Surgical Division, Naples, Italy.
Drugs Exp Clin Res. 1993;19(5):219-22.
The effect of L-carnitine on glucose and insulin plasma levels was evaluated in 47 healthy volunteers who were administered a 10% glucose solution infusion over 3 h. The experiment was carried out following a cross-over procedure: each patient received two 750 cc 10% glucose solution infusions, a week apart; to one of these infusions 6 g L-carnitine had been added. The glucose infusion significantly increased the plasma glucose concentration of both groups, however, analysis of variance demonstrated that the increase in Group B was inferior (p < 0.01). Insulin plasma levels increased rapidly after the beginning of the glucose infusion in both groups. From T90 to T180, when the maximum hypoglycaemic effect of L-carnitine was observed, this increase was lower in Group B than in Group A. The authors conclude that L-carnitine is capable of reducing the increase in plasma glucose concentration induced by a glucose solution infusion in healthy subjects. This effect does not seem to be related to an insulin-dependent mechanism.
在47名健康志愿者中评估了左旋肉碱对血糖和胰岛素血浆水平的影响，这些志愿者接受了为期3小时的10%葡萄糖溶液输注。实验按照交叉程序进行：每位患者接受两次750毫升10%葡萄糖溶液输注，间隔一周；其中一次输注添加了6克左旋肉碱。葡萄糖输注显著提高了两组的血浆葡萄糖浓度，然而，方差分析表明B组的升高幅度较小（p<0.01）。两组在葡萄糖输注开始后胰岛素血浆水平迅速升高。从T90到T180，观察到左旋肉碱的最大降血糖作用时，B组的这种升高低于A组。作者得出结论，左旋肉碱能够降低健康受试者中葡萄糖溶液输注引起的血浆葡萄糖浓度升高。这种作用似乎与胰岛素依赖性机制无关。
