Fukuzaki A, Morrissey J, Klahr S
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Int Urol Nephrol. 1993;25(6):525-31.
The regional production of prostaglandin E2 and thromboxane B2 was investigated in the kidney with unilateral or bilateral ureteral obstruction for 24 hours in rats. The production of these eicosanoids was highest in the inner medulla both with or without ureteral obstruction, although the production rate by the tubules was relatively low in the obstructed kidney compared to the sham-operated control. A greater production of these vasoactive compounds was noted by glomeruli from the kidneys with unilateral or bilateral obstruction and the contralateral kidney with unilateral obstruction. Glomeruli obtained from the kidney with unilateral obstruction produced more thromboxane B2 than the kidney with bilateral obstruction, and the resultant TxB2/PGE2 ratio was higher in the unilaterally obstructed kidney. This difference in the glomerular thromboxane B2 production may be responsible for the haemodynamic changes between unilateral and bilateral ureteral obstructions. An increased prostaglandin E2 production by glomeruli from the contralateral kidney with unilateral obstruction may contribute to a compensatory response.
研究了大鼠单侧或双侧输尿管梗阻24小时后肾脏中前列腺素E2和血栓素B2的局部生成情况。无论有无输尿管梗阻，这些类花生酸的生成在内髓质中最高，尽管与假手术对照组相比，梗阻肾脏中肾小管的生成率相对较低。单侧或双侧梗阻肾脏的肾小球以及单侧梗阻对侧肾脏的肾小球生成这些血管活性化合物的量更多。单侧梗阻肾脏的肾小球生成的血栓素B2比双侧梗阻肾脏的更多，并且在单侧梗阻肾脏中，所得的血栓素B2/前列腺素E2比值更高。肾小球血栓素B2生成的这种差异可能是单侧和双侧输尿管梗阻之间血流动力学变化的原因。单侧梗阻对侧肾脏的肾小球中前列腺素E2生成增加可能有助于产生代偿反应。
