Masterson M E, Mageras G S, LoSasso T, Joreskog E, Larsson L G, Tsirakis B, Febo R, Mohan R, Ling C C, Leibel S A
Dept. of Medical Physics, Memorial Sloan-Kettering Cancer Center, NY.
Int J Radiat Oncol Biol Phys. 1994 Mar 30;28(5):1219-27. doi: 10.1016/0360-3016(94)90498-7.
A 50 MeV racetrack microtron has been installed and tested at Memorial Sloan-Kettering Cancer Center. It is designed to execute multi-segment conformal therapy automatically under computer control using scanned X ray and electron beams from 10 to 50 MeV. Prior to acceptance of the machine from the manufacturer, formal reliability testing was carried out. Only in this way could confidence be gained in its usefulness for routine 3D computer-controlled conformal therapy.
To assess reliability, a set of 25 multi-segment test cases, each consisting of 10 to 17 fixed segments, was developed. The field arrangements and modalities for some of the test cases were identical to 3D conformal treatments that were being delivered with multiple static fields on conventional linear accelerators at our institution. Other cases were designed to explore reliability under more complex sets of conditions. These cases were "treated" repeatedly during a total period of 45 hours, over 5 days. During the treatments, ion chambers attached to the head of the machine provided dosimetric data for each field. Data from sensors connected to every set-up parameter (for example, couch positions, gantry angle, collimator leaf positions, etc.) were recorded and verified by an external computer.
While preliminary tests indicated an interlock rate of 5%, final reliability test results demonstrated an interlock fault rate of approximately 0.5%. The reproducibility of dosimetric data and geometric setup parameters was within specifications. As an example, leaf position reproducibility in the patient plane was within 0.5 mm for 97% of the setups. The times required to carry out treatments were recorded and compared with the times to carry out identical treatments on a conventional linear accelerator with cerrobend blocks. Areas where additional time savings can be achieved were identified.
As an integral part of acceptance testing, the Scanditronix MM50 was rigorously tested for reliability. The machine successfully passed these tests, providing increased confidence in its usefulness for routine 3D conformal therapy.
一台50兆电子伏的跑道式微型加速器已在纪念斯隆凯特琳癌症中心安装并进行了测试。它旨在通过计算机控制,利用能量范围为10至50兆电子伏的扫描X射线和电子束自动执行多段适形治疗。在从制造商接收该机器之前,进行了正式的可靠性测试。只有这样,才能对其在常规三维计算机控制适形治疗中的实用性有信心。
为评估可靠性,制定了一组25个多段测试案例,每个案例由10至17个固定段组成。部分测试案例的射野布置和模式与本机构使用传统直线加速器的多个静态射野进行的三维适形治疗相同。其他案例旨在探索在更复杂条件下的可靠性。这些案例在5天内共45小时的时间里被反复“治疗”。在治疗过程中,连接到机器头部的电离室为每个射野提供剂量学数据。连接到每个设置参数(例如,治疗床位置、机架角度、准直器叶片位置等)的传感器数据由外部计算机记录并验证。
初步测试显示联锁率为5%,而最终可靠性测试结果表明联锁故障率约为0.5%。剂量学数据和几何设置参数的可重复性在规格范围内。例如,在97%的设置中,患者平面内叶片位置的可重复性在0.5毫米以内。记录了进行治疗所需的时间,并与使用铈钨合金挡块的传统直线加速器进行相同治疗所需的时间进行了比较。确定了可以进一步节省时间的领域。
作为验收测试的一个组成部分,对Scanditronix MM50进行了严格的可靠性测试。该机器成功通过了这些测试,这使其在常规三维适形治疗中的实用性更具可信度。