匹氨西林，一种具有广谱活性的新型半合成青霉素。
Pirbenicillin, a new semisynthetic penicillin with broad-spectrum activity.
作者信息
Bodey G P, Rodriguez V, Weaver S
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):668-74. doi: 10.1128/AAC.9.4.668.
Abstract
Pirbenicillin is a new semisynthetic penicillin which inhibited 67% of isolates of Proteus aeruginosa tested in our laboratory, 93% of P. mirabilis, 31% of Enterobacter spp., 41% of Serratia spp., and 58% of Escherichia coli at a concentration of 6.25 mug/ml. Its activity appeared to be inoculum dependent and it was virtually inactive against 10(7) inocula of P. aeruginosa. It was more active than carbenicillin or ticarcillin, but less active than BL-P1654 against P. aeruginosa. Carbenicillin and ticarcillin appeared to be more active than pirbenicillin against Proteus spp., but pirbenicillin was active against some isolates of Klebsiella spp.
摘要
匹氨西林是一种新型半合成青霉素，在我们实验室中，其在浓度为6.25微克/毫升时，能抑制67%的铜绿假单胞菌分离株、93%的奇异变形杆菌、31%的肠杆菌属、41%的沙雷菌属以及58%的大肠杆菌。其活性似乎与接种量有关，对10⁷接种量的铜绿假单胞菌实际上无活性。它比羧苄西林或替卡西林更具活性，但对铜绿假单胞菌的活性比BL - P1654低。羧苄西林和替卡西林对变形杆菌属的活性似乎比匹氨西林更高，但匹氨西林对某些克雷伯菌属分离株有活性。
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本文引用的文献
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New semi-synthetic penicillin active against Pseudomonas pyocyanea.对绿脓杆菌有效的新型半合成青霉素。
Nature. 1967 Jul 1;215(5096):25-30. doi: 10.1038/215025a0.
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Carbenicillin therapy for pseudomonas infections.羧苄青霉素治疗假单胞菌感染。
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In vitro studies of semisynthetic alpha-(substituted-ureido) penicillins.半合成α-（取代脲基）青霉素的体外研究。
Appl Microbiol. 1971 Apr;21(4):710-7. doi: 10.1128/am.21.4.710-717.1971.
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Ticarcillin therapy of infections.替卡西林治疗感染
Antimicrob Agents Chemother. 1973 Oct;4(4):427-31. doi: 10.1128/AAC.4.4.427.
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The hemostatic defect produced by carbenicillin.羧苄青霉素产生的止血缺陷。
N Engl J Med. 1974 Aug 8;291(6):265-70. doi: 10.1056/NEJM197408082910601.
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