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1
CI-867, a new semisynthetic penicillin: in vitro studies.CI-867，一种新型半合成青霉素：体外研究
Antimicrob Agents Chemother. 1980 Dec;18(6):939-43. doi: 10.1128/AAC.18.6.939.
2
Azlocillin: in vitro studies of a new semisynthetic penicillin.阿洛西林：一种新型半合成青霉素的体外研究
Antimicrob Agents Chemother. 1977 May;11(5):865-70. doi: 10.1128/AAC.11.5.865.
3
Mezlocillin: in vitro studies of a new broad-spectrum penicillin.美洛西林：一种新型广谱青霉素的体外研究
Antimicrob Agents Chemother. 1977 Jan;11(1):74-9. doi: 10.1128/AAC.11.1.74.
4
In vitro studies of piperacilin, a new semisynthetic penicillin.新型半合成青霉素哌拉西林的体外研究。
Antimicrob Agents Chemother. 1978 Jun;13(6):944-50. doi: 10.1128/AAC.13.6.944.
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In vitro activity of furazlocillin (Bay k 4999) compared with those of mezlocillin, piperacillin, and standard beta-lactam antibiotics.呋苄西林（Bay k 4999）与美洛西林、哌拉西林及标准β-内酰胺类抗生素的体外活性比较。
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Comparative in vitro study of temocillin (BRL 17421), a new penicillin.新型青霉素替莫西林（BRL 17421）的体外比较研究
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7
Piperacillin: in vitro evaluation.哌拉西林：体外评估。
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J Antibiot (Tokyo). 1977 Sep;30(9):724-9. doi: 10.7164/antibiotics.30.724.
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Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins.阿洛西林、美洛西林和哌拉西林：新型广谱青霉素。
Ann Intern Med. 1982 Nov;97(5):755-60. doi: 10.7326/0003-4819-97-5-755.
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Azlocillin: a new broad spectrum penicillin.
J Antimicrob Chemother. 1983 May;11 Suppl B:21-31. doi: 10.1093/jac/11.suppl_b.21.

引用本文的文献

1
Comparative in vitro study of temocillin (BRL 17421), a new penicillin.新型青霉素替莫西林（BRL 17421）的体外比较研究
Antimicrob Agents Chemother. 1982 Apr;21(4):641-5. doi: 10.1128/AAC.21.4.641.

本文引用的文献

1
In vitro evaluation of cefoperazone.头孢哌酮的体外评价。
Antimicrob Agents Chemother. 1980 Mar;17(3):423-7. doi: 10.1128/AAC.17.3.423.
2
New semi-synthetic penicillin active against Pseudomonas pyocyanea.对绿脓杆菌有效的新型半合成青霉素。
Nature. 1967 Jul 1;215(5096):25-30. doi: 10.1038/215025a0.
3
In vitro studies of semisynthetic alpha-(substituted-ureido) penicillins.半合成α-（取代脲基）青霉素的体外研究。
Appl Microbiol. 1971 Apr;21(4):710-7. doi: 10.1128/am.21.4.710-717.1971.
4
Causes of death in patients with malignant lymphoma.恶性淋巴瘤患者的死亡原因。
Am J Med Sci. 1974 Aug;268(2):97-106. doi: 10.1097/00000441-197408000-00003.
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Proceedings: Causes of death in cancer patients.会议记录：癌症患者的死因
Cancer. 1974 Feb;33(2):568-73. doi: 10.1002/1097-0142(197402)33:2<568::aid-cncr2820330236>3.0.co;2-2.
6
Infectious complications in renal transplant recipients.肾移植受者的感染性并发症
Transplant Proc. 1973 Sep;5(3):1233-8.
7
Antibiotic therapy of infections in patients undergoing cancer chemotherapy.癌症化疗患者感染的抗生素治疗
Antibiot Chemother (1971). 1974;18:49-88. doi: 10.1159/000395181.
8
Mezlocillin: in vitro studies of a new broad-spectrum penicillin.美洛西林：一种新型广谱青霉素的体外研究
Antimicrob Agents Chemother. 1977 Jan;11(1):74-9. doi: 10.1128/AAC.11.1.74.
9
Pirbenicillin, a new semisynthetic penicillin with broad-spectrum activity.匹氨西林，一种具有广谱活性的新型半合成青霉素。
Antimicrob Agents Chemother. 1976 Apr;9(4):668-74. doi: 10.1128/AAC.9.4.668.
10
Piperacillin: in vitro evaluation.哌拉西林：体外评估。
Antimicrob Agents Chemother. 1978 Jul;14(1):78-87. doi: 10.1128/AAC.14.1.78.

CI-867，一种新型半合成青霉素：体外研究

CI-867, a new semisynthetic penicillin: in vitro studies.

作者信息

Weaver S S, Bodey G P

出版信息

Antimicrob Agents Chemother. 1980 Dec;18(6):939-43. doi: 10.1128/AAC.18.6.939.

DOI:10.1128/AAC.18.6.939
PMID:7235679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352993/
Abstract

CI-867, a new semisynthetic penicillin, has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. It was especially active against Pseudomonas aeruginosa and as active as mezlocillin and piperacillin against Klebsiella pneumoniae. CI-867 was bactericidal against most organisms. Its activity was greatly reduced when the inoculum was increased from 10(5) to 10(7) organisms per ml.

摘要

CI - 867是一种新型半合成青霉素，在体外对革兰氏阳性球菌（除耐青霉素G的金黄色葡萄球菌外）和革兰氏阴性杆菌具有广谱活性。它对铜绿假单胞菌特别有效，对肺炎克雷伯菌的活性与美洛西林和哌拉西林相当。CI - 867对大多数微生物具有杀菌作用。当接种量从每毫升10⁵个菌增加到10⁷个菌时，其活性大大降低。