CI-867，一种新型半合成青霉素：体外研究
CI-867, a new semisynthetic penicillin: in vitro studies.
作者信息
Weaver S S, Bodey G P
出版信息
Antimicrob Agents Chemother. 1980 Dec;18(6):939-43. doi: 10.1128/AAC.18.6.939.
Abstract
CI-867, a new semisynthetic penicillin, has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. It was especially active against Pseudomonas aeruginosa and as active as mezlocillin and piperacillin against Klebsiella pneumoniae. CI-867 was bactericidal against most organisms. Its activity was greatly reduced when the inoculum was increased from 10(5) to 10(7) organisms per ml.
摘要
CI - 867是一种新型半合成青霉素，在体外对革兰氏阳性球菌（除耐青霉素G的金黄色葡萄球菌外）和革兰氏阴性杆菌具有广谱活性。它对铜绿假单胞菌特别有效，对肺炎克雷伯菌的活性与美洛西林和哌拉西林相当。CI - 867对大多数微生物具有杀菌作用。当接种量从每毫升10⁵个菌增加到10⁷个菌时，其活性大大降低。
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