Foukaridis G N, Muntingh G L, Osuch E
Department of Pharmacology and Therapeutics, Medical University of Southern Africa, Medunsa.
J Ethnopharmacol. 1994 Feb;41(3):135-46. doi: 10.1016/0378-8741(94)90029-9.
A large percentage of acute poisonings in black South Africans is due to traditional medicines and plants. The combination of isocratic high performance liquid chromatography (HPLC) with on line UV spectrum detection via a diode array configuration has been applied to the detection and identification of traditional medicines (and plants) in poisoned patients. Four standard isocratic systems are used. Combination of the retention times in the HPLC chromatogram and a comparison of the full spectra between 190-600 nm of the peaks obtained from extracted patient samples (urine or blood) with that of traditional medicine extracts (collected and stored in a reference data file) makes reliable identification possible. Such information could improve the quality of data accumulation and therapeutic strategies.
南非黑人中很大一部分急性中毒事件是由传统药物和植物引起的。等度高效液相色谱法（HPLC）与通过二极管阵列配置进行在线紫外光谱检测相结合，已被应用于中毒患者体内传统药物（及植物）的检测和鉴定。使用了四种标准等度系统。通过HPLC色谱图中的保留时间以及将从患者提取样本（尿液或血液）中获得的峰在190 - 600纳米之间的全光谱与传统药物提取物（收集并存储在参考数据文件中）的全光谱进行比较，从而实现可靠的鉴定。这些信息可以提高数据积累的质量和治疗策略。
