Ohba S, Hiramatsu M, Edamatsu R, Mori I, Mori A
Department of Neuroscience, Okayama University Medical School, Japan.
Neurochem Res. 1994 Mar;19(3):237-41. doi: 10.1007/BF00971570.
The effect of various metal ions on neuronal membrane fluidity was examined using 2-(14-carboxypropyl)-2-ethyl-4,4-dimethyl-3-oxazolidinyloxy, which has been used for the examination of membrane fluidity in hydrophobic areas by electron spin resonance spectrometry. Potassium, cobalt, calcium, magnesium, nickel, copper, ferric, and aluminium ions decreased the membrane fluidity while ferrous ions increased it at each high concentration. Sodium and zinc ions had no effect. Ethylenediaminetetraacetic acid decreased membrane fluidity at high concentrations. Nicardipine lowered membrane fluidity and flunarizine elevated it at each high concentration. There was no change in membrane fluidity by other calcium antagonists, nimodipine and nifedipine.
使用2-(14-羧丙基)-2-乙基-4,4-二甲基-3-恶唑烷基氧基来检测各种金属离子对神经元膜流动性的影响，该物质已被用于通过电子自旋共振光谱法检测疏水区域的膜流动性。钾离子、钴离子、钙离子、镁离子、镍离子、铜离子、铁离子和铝离子在高浓度时会降低膜流动性，而亚铁离子在高浓度时会增加膜流动性。钠离子和锌离子没有影响。乙二胺四乙酸在高浓度时会降低膜流动性。尼卡地平在高浓度时会降低膜流动性，而氟桂利嗪在高浓度时会增加膜流动性。其他钙拮抗剂尼莫地平和硝苯地平对膜流动性没有影响。
