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基于对特察河居民牙齿和骨骼中锶-90的体内测量的膳食摄入评估和剂量测定模型

Dietary intake evaluation and dosimetric modelling for the Techa River residents based on in vivo measurements of strontium-90 in teeth and skeleton.

作者信息

Kozheurov V P, Degteva M

机构信息

Urals Research Center for Radiation Medicine, Medgorodok, Chelyabinsk, Russian Federation.

出版信息

Sci Total Environ. 1994 Mar 1;142(1-2):63-72. doi: 10.1016/0048-9697(94)90074-4.

Abstract

Explanations are given for the models and algorithms that are utilised to reconstruct the doses due to the incorporation of 90Sr in the inhabitants of the Techa riverside villages. A model for the 90Sr accumulation and excretion in the tooth enamel is employed to derive the relative intakes of 90Sr in the years 1950-1959. The measurements of beta-ray activity on the surface of the front teeth of persons born between 1940-1959 are used to derive the relative intakes in different calendar years and the transfer functions to the tooth enamel as a function of age. This derivation is based on a non-linear optimisation algorithm, to fit the observed average count rates for different birth cohorts in a village. The data for the village of Muslyumovo are used as the reference data set. Absolute values of the strontium intake are derived from the relative values by a fit to the measurements of the 90Sr body burdens that were performed after 1974. A model has been developed for the age-dependent metabolism of strontium in the skeleton. The computations in terms of this model are in reliable agreement with experimental data on strontium in man.

摘要

文中解释了用于重建因90Sr进入捷恰河畔村庄居民体内而产生的剂量的模型和算法。采用了一个关于90Sr在牙釉质中积累和排泄的模型来推导1950 - 1959年期间90Sr的相对摄入量。对1940 - 1959年出生人群的门牙表面β射线活性进行测量,以推导不同历年的相对摄入量以及作为年龄函数的向牙釉质的转移函数。这种推导基于一种非线性优化算法,以拟合一个村庄中不同出生队列观察到的平均计数率。穆斯柳莫沃村的数据用作参考数据集。通过拟合1974年之后进行的90Sr体内负荷测量值,从相对值推导出锶摄入量的绝对值。已开发出一个关于锶在骨骼中随年龄变化的代谢模型。基于该模型的计算结果与人体中锶的实验数据可靠吻合。

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