Arai H, Shirai T, Hananouchi M, Hirose M, Murasaki G, Ito N
Gan. 1978 Aug;69(4):593-5.
Studies were made on the effect of protease inhibitors (pepstatin, leupeptin, and antipain) on the induction of tumors in mice by the alpha-isomer of 1,2,3,4,5,6-hexachlorocyclohexane (alpha-BHC) and by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Animals were given 0.05% alpha-BHC in the diet or 0.05% BBN in their drinking water and then fed on a powder diet supplemented with 0.1% protease inhibitors. The incidence of liver nodular hyperplasias was significantly higher in the group treated with alpha-BHC and leupeptin than in the group treated with alpha-BIC alone, but pepstatin and antipain did not affect induction of liver nodular hyperplasias by alpha-BHC. None of the three protease inhibitors influenced the induction of bladder tumors by BBN.
研究了蛋白酶抑制剂（胃蛋白酶抑制剂、亮抑蛋白酶肽和抗蛋白酶）对1,2,3,4,5,6 - 六氯环己烷α - 异构体（α - BHC）和N - 丁基 - N - （4 - 羟基丁基）亚硝胺（BBN）诱导小鼠肿瘤的影响。给动物喂食含0.05%α - BHC的饲料或饮用含0.05%BBN的水，然后喂食添加了0.1%蛋白酶抑制剂的粉末饲料。用α - BHC和亮抑蛋白酶肽处理的组中肝结节性增生的发生率显著高于仅用α - BHC处理的组，但胃蛋白酶抑制剂和抗蛋白酶不影响α - BHC诱导肝结节性增生。三种蛋白酶抑制剂均不影响BBN诱导膀胱肿瘤。
