Kakizoe T, Matsukura N, Aoyagi M, Kawachi T, Sugimura T
Gan. 1980 Feb;71(1):138-40.
Male Wistar rats were given a diet containing 0.1% leupeptin, a microbial protease inhibitor, and drinking water containing 0.01% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 8 weeks. Leupeptin did not have any detectable effect on the induction of bladder tumors by BBN in week 40, in terms of the weight of the bladder including the tumor, the number of tumors per bladder, the extent of invasion, or the incidences of hyperplasia, papilloma, and cancer. This result is in marked contrast to the previous findings that leupeptin enhanced BBN-induced bladder carcinogenesis when administered continuously after BBN-treatment.
给雄性Wistar大鼠喂食含0.1%亮抑酶肽（一种微生物蛋白酶抑制剂）的饲料，并饮用含0.01% N-丁基-N-（4-羟基丁基）亚硝胺（BBN）的水，持续8周。在第40周时，就包括肿瘤在内的膀胱重量、每个膀胱的肿瘤数量、侵袭程度或增生、乳头状瘤和癌症的发生率而言，亮抑酶肽对BBN诱导的膀胱肿瘤没有任何可检测到的影响。这一结果与之前的研究结果形成了显著对比，之前的研究发现，在BBN处理后持续给予亮抑酶肽会增强BBN诱导的膀胱致癌作用。
