Uitti R J, Snow B J, Shinotoh H, Vingerhoets F J, Hayward M, Hashimoto S, Richmond J, Markey S P, Markey C J, Calne D B
Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1994 May;35(5):616-9. doi: 10.1002/ana.410350516.
We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits were indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.
我们报告了首例因滥用溶剂导致帕金森综合征患者的病例描述。我们的患者在大量滥用漆稀释剂后急性出现帕金森综合征。她的临床症状与特发性帕金森综合征（帕金森病）难以区分，并且对左旋多巴有反应。帕金森综合征已持续超过3个月。脑部计算机断层扫描结果正常。正电子发射断层扫描研究显示氟多巴摄取正常，但雷氯必利结合减少，表明纹状体多巴胺能功能存在异常紊乱。该患者提示有机溶剂可能在易感个体中引发帕金森综合征。
