Murphy L J
Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
J Steroid Biochem Mol Biol. 1994 Apr;48(5-6):419-23. doi: 10.1016/0960-0760(94)90189-9.
There is compelling evidence that growth factors are involved in mediating estrogen action in target tissues. The role of growth factors in the development and progression of endometrial cancer is less clear. Steroid hormones can regulate the expression of the transforming growth factors and epidermal growth factor receptors in endometrial cancer cells in culture. It is also possible to demonstrate that these growth factors function in an autocrine fashion to regulate proliferation of endometrial cancer cells in culture. Constitutive expression or overexpression of such autocrine/paracrine factors and/or their receptors may be important in the growth progression of endometrial neoplasia. However, to date the evidence to support the hypothesis is limited.
有确凿证据表明生长因子参与介导雌激素在靶组织中的作用。生长因子在子宫内膜癌的发生和发展中的作用尚不清楚。类固醇激素可调节培养的子宫内膜癌细胞中转化生长因子和表皮生长因子受体的表达。也有可能证明这些生长因子以自分泌方式发挥作用，调节培养的子宫内膜癌细胞的增殖。此类自分泌/旁分泌因子和/或其受体的组成性表达或过表达可能在子宫内膜肿瘤的生长进展中起重要作用。然而，迄今为止支持该假说的证据有限。
