细菌干扰：口服抗生素对正常咽喉菌群及其干扰A组链球菌能力的影响。
Bacterial interference: effects of oral antibiotics on the normal throat flora and its ability to interfere with group A streptococci.
作者信息
Sanders C C, Sanders W E, Harrowe D J
出版信息
Infect Immun. 1976 Mar;13(3):808-12. doi: 10.1128/iai.13.3.808-812.1976.
Abstract
The effects of orally administered penicillin and tetracycline on the composition of the normal throat flora and its interference with the growth of group A streptococci were evaluated by throat culture and an agar overlay technique. Tetracycline caused only a slight, transient quantitative decrease in the composition of the flora and interference activity. Penicillin caused significant quantitative and qualitative decreases in both the composition of the flora and interference activity. The diminution in interference activity persisted up to 3 weeks after therapy. The differences observed between the antibiotic regimens correlated with differences in initial susceptibility of the flora to the antibiotic used and emergence of the resistance during therapy. Results indicated that although effects of antibiotics on the composition of the flora are transient, effects on its ability to interfere with group A streptococci may persist long after therapy is discontinued. It is thus possible that penicillin therapy may enhance susceptibility of certain individuals to subsequent infection with group A streptococci.
摘要
通过咽喉培养和琼脂覆盖技术，评估口服青霉素和四环素对正常咽喉菌群组成的影响及其对A组链球菌生长的干扰作用。四环素仅使菌群组成和干扰活性出现轻微、短暂的定量减少。青霉素则使菌群组成和干扰活性在数量和质量上均显著降低。干扰活性的减弱在治疗后持续长达3周。观察到的抗生素治疗方案之间的差异与菌群对所用抗生素的初始敏感性差异以及治疗期间耐药性的出现有关。结果表明，虽然抗生素对菌群组成的影响是短暂的，但对其干扰A组链球菌能力的影响在治疗停止后可能会持续很长时间。因此，青霉素治疗有可能会增加某些个体对随后A组链球菌感染的易感性。
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