Bowe Whitney P, Filip Jennifer C, DiRienzo Joseph M, Volgina Alla, Margolis David J
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
J Drugs Dermatol. 2006 Oct;5(9):868-70.
We report the in vitro inhibition of Propionibacterium acnes (P. acnes) by a bacteriocin-like inhibitory substance (BLIS-like substance) produced by Streptococcus salivarius (S. salivarius). Bacteriocins are proteinaceous substances produced by bacteria that are capable of inhibiting the growth of similar bacterial strains. Unlike classical antibiotics, they have a relatively narrow spectrum of killing activity, resulting in a reduction in the intensity of selection for resistance. These findings suggest that BLIS may potentially be used for its anti-P. acnes activity in the treatment of acne.
我们报告了唾液链球菌(S. salivarius)产生的一种类细菌素抑制物质(BLIS样物质)对痤疮丙酸杆菌(P. acnes)的体外抑制作用。细菌素是由细菌产生的蛋白质类物质,能够抑制相似细菌菌株的生长。与传统抗生素不同,它们具有相对较窄的杀伤活性谱,从而降低了耐药性选择的强度。这些发现表明,BLIS可能因其抗痤疮丙酸杆菌活性而潜在地用于痤疮治疗。