Januszewicz A, Stys A, Stys T, Lapinski M, Lon S
Department of Hypertension & Angiology, Warsaw Academy of Medicine, Poland.
Blood Press. 1993 Jun;2(2):146-54. doi: 10.3109/08037059309077543.
Endothelin (ET) exerts direct vasoconstrictory effects and stimulates release of vasoactive substances. It has been demonstrated that ET stimulates the release of atrial natriuretic peptide (ANP) both under in vitro and in vivo conditions. The present study aimed at elucidating whether the cardiovascular effects of endothelin-3 (ET-3) in normotensive (WKY) and spontaneously hypertensive (SHR) rats are modulated by ANP. The experiments were performed on 17 conscious WKY and 17 SHR rats. The effects of i.v. administration of 1 microgram of ET-3 on blood pressure (BP) and heart rate (HR) were investigated under control conditions and during ANP infusion (0.3 microgram/kg/min). In both strains ET-3 elicited a transient significant hypotensive effect followed by an increase in BP. BP fall was significantly greater and pressor effect significantly smaller in SHR than in WKY. In WKY, but not in SHR rats, both hypotensive and pressor phases were significantly attenuated during ANP administration. The results are evidence of differential involvement of endogenous blood pressure regulating factors in the cardiovascular effects of ET-3 in WKY and SHR rats during ANP infusion.
内皮素（ET）具有直接的血管收缩作用，并能刺激血管活性物质的释放。已有研究表明，ET在体外和体内条件下均能刺激心房利钠肽（ANP）的释放。本研究旨在阐明正常血压（WKY）和自发性高血压（SHR）大鼠中，内皮素-3（ET-3）的心血管效应是否受ANP调节。实验在17只清醒的WKY大鼠和17只SHR大鼠上进行。在对照条件下以及ANP输注期间（0.3微克/千克/分钟），研究静脉注射1微克ET-3对血压（BP）和心率（HR）的影响。在两种品系中，ET-3均引发短暂的显著降压作用，随后血压升高。SHR的血压下降幅度显著大于WKY，升压作用显著小于WKY。在WKY大鼠中，而非SHR大鼠中，ANP给药期间降压期和升压期均显著减弱。这些结果证明，在ANP输注期间，内源性血压调节因子在WKY和SHR大鼠ET-3的心血管效应中发挥不同作用。
