Krystofová S, Varecka L, Vollek V, Grimová J, Betina V
Department of Microbiology, Biochemistry and Biology, Slovak Technical University, Bratislava.
Folia Microbiol (Praha). 1994;39(1):44-8. doi: 10.1007/BF02814528.
Nonsteroid antiinflammatory agents (NSAIA's) (inhibitors of cyclooxygenase and lipoxygenase) of several structural series inhibited growth of Trichoderma viride. The most potent growth inhibitors were indomethacin and its derivative repanidal which inhibited in the range of 0.1 mmol/L. The weakest inhibitors were acetylsalicylic acid and lysine salicylate which exerted only a weak effect at concentrations above 1 mmol/L. The inhibition of growth was accompanied by a stimulation of conidiation in the dark. A light pulse increased the efficiency of these drugs to stimulate the conidiation. Saccharomyces cerevisiae was as sensitive to NSAIA's as T. viride while Botrytis cinerea was less sensitive. The results indicate that arachidonate metabolism may play a role in the growth of fungi and may participate also in the process of conidiation.
几个结构系列的非甾体抗炎药（NSAIA，环氧化酶和脂氧合酶抑制剂）抑制了绿色木霉的生长。最有效的生长抑制剂是吲哚美辛及其衍生物瑞帕尼达尔，它们在0.1 mmol/L的范围内具有抑制作用。最弱的抑制剂是乙酰水杨酸和赖氨酸水杨酸盐，它们在浓度高于1 mmol/L时仅产生微弱的作用。生长抑制伴随着在黑暗中分生孢子形成的刺激。光脉冲提高了这些药物刺激分生孢子形成的效率。酿酒酵母对NSAIA的敏感性与绿色木霉相同，而灰葡萄孢则较不敏感。结果表明，花生四烯酸代谢可能在真菌生长中起作用，也可能参与分生孢子形成过程。
