Tauber J W, Falk J A, Falk R E, Zabriskie J B
J Exp Med. 1976 Jun 1;143(6):1341-51. doi: 10.1084/jem.143.6.1341.
A number of experiments have suggested that there is an antigenic relationship between the HLA complex and streptococcal bacterial structures. Using inhibition of cytotoxicity of HLA antisera as our assay system, it was demonstrated that the inhibitory effect on HLA cytotoxicity by streptococcal antigens is, in reality, due to activation and consumption of components of the alternate complement pathway. In addition, antisera prepared against streptococcal membrane antigens had no cytotoxic effect on a large panel of human lymphocytes, nor did these antisera exhibit immunofluorescent staining of lymphocytes directly. These experiments are compatible with our concept that the HLA complex may have evolved through selective evolutionary pressure as a means of escaping bacterial mimicry.
多项实验表明，HLA复合体与链球菌细菌结构之间存在抗原关系。以HLA抗血清细胞毒性的抑制作为我们的检测系统，结果表明链球菌抗原对HLA细胞毒性的抑制作用实际上是由于替代补体途径成分的激活和消耗。此外，针对链球菌膜抗原制备的抗血清对大量人类淋巴细胞没有细胞毒性作用，这些抗血清也未直接表现出对淋巴细胞的免疫荧光染色。这些实验与我们的观点相符，即HLA复合体可能是通过选择性进化压力进化而来，作为逃避细菌模拟的一种方式。
