链球菌结构引起的非特异性补体激活。II. 旁路途径的不依赖备解素起始
Nonspecific complement activation by streptococcal structures. II. Properdin-independent initiation of the alternate pathway.
作者信息
Tauber J W, Polley M J, Zabriskie J B
出版信息
J Exp Med. 1976 Jun 1;143(6):1352-66. doi: 10.1084/jem.143.6.1352.
Abstract
Complement consumption by isolated membranes and walls from Group A streptococci and various other gram-positive microbes has been tested. These microbial structures were found to activate the alternate complement pathway. However, unlike endotoxin, inulin, or other plant polysaccharides, activation of complement by our material was found to bypass properdin. The activating factor(s) also differs from cobra venom in its/their requirement for factor D. Preliminary experiments suggest this factor isolated from membranes to be a protein and to have a mol wt greater than 40-60,000 daltons. Our studies have led us to speculate that the phylogenetic role of the alternate complement pathway may be the primordial nonspecific defense system which has retained certain fundamental aspects up to the present time.
摘要
对A组链球菌及其他多种革兰氏阳性微生物的分离细胞膜和细胞壁的补体消耗情况进行了测试。发现这些微生物结构可激活替代补体途径。然而，与内毒素、菊粉或其他植物多糖不同，我们的材料激活补体的过程被发现绕过了备解素。激活因子在对D因子的需求方面也与眼镜蛇毒不同。初步实验表明，从细胞膜分离出的这种因子是一种蛋白质，分子量大于40 - 60,000道尔顿。我们的研究使我们推测，替代补体途径的系统发育作用可能是一种原始的非特异性防御系统，至今仍保留着某些基本特征。
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