Maguire A, Rugg-Gunn A J
Department of Child Dental Health, University of Newcastle upon Tyne, UK.
Public Health. 1994 Mar;108(2):121-30. doi: 10.1016/s0033-3506(05)80017-4.
The widespread use of sugar-based liquid oral medication, especially long term, continues to cause concern in view of the well-established link between sugar and dental caries. As part of an overall study of liquid oral medicine use in children, analysis of the number of prescriptions and volume of liquid oral medicines dispensed through the general medical and dental services, on a regional and national basis, was undertaken, together with a survey of liquid oral medicines ordering in hospital pharmacies and 'over-the-counter' (OTC) liquid oral medicines in community pharmacies. The number of prescriptions and volume of liquid oral medicines prescribed during a one-year period (1987) were: for Great Britain, 43.9 million prescriptions and 10.3 million litres; for the Northern Region, 2.7 million prescriptions and 0.7 million litres. The total volume of liquid oral medicines, for both long- and short-term use, supplied on prescription and over the counter within the Northern Region during a one-year period (1987) was approximately 1.1 million litres. Of this, 0.28 million litres were OTC liquid oral medicines destined for long- and short-term use. In quantity terms, 59% of prescribed liquid oral medicines and 65% of hospital pharmacy liquid oral medicines, dispensed potentially for long-term use, were sugar-based, whereas 45% of the quantity supplied over the counter was sugar-based. Although there has been progress towards more sugar-free preparations being available over the counter, sugar-based prescribing and dispensing dominates prescription liquid medicines, which are more likely to be taken long term.
鉴于糖与龋齿之间已明确的关联,含糖液体口服药物的广泛使用,尤其是长期使用,持续引发关注。作为对儿童液体口服药物使用情况全面研究的一部分,对通过全科医疗和牙科服务在区域及全国范围内发放的液体口服药物的处方数量和配发量进行了分析,同时对医院药房的液体口服药物订购情况以及社区药房的“非处方药”(OTC)液体口服药物进行了调查。1987年这一年期间开出的液体口服药物的处方数量和配发量为:英国,4390万张处方和1030万升;北部地区,270万张处方和70万升。1987年这一年期间,北部地区通过处方和非处方供应的用于长期和短期使用的液体口服药物的总量约为110万升。其中,28万升是非处方液体口服药物,用于长期和短期使用。从数量上看,可能用于长期使用的已配发的处方液体口服药物中有59%以及医院药房的液体口服药物中有65%是含糖的,而柜台供应的药物中有45%是含糖的。尽管在非处方可获得更多无糖制剂方面已取得进展,但含糖的处方和配药在处方液体药物中占主导地位,而这些药物更有可能长期服用。