阿替洛尔与普萘洛尔在胰岛素诱导的低血糖期间的比较。
Comparison of atenolol and propranolol during insulin-induced hypoglycaemia.
作者信息
Deacon S P, Barnett D
出版信息
Br Med J. 1976 Jul 31;2(6030):272-3. doi: 10.1136/bmj.2.6030.272.
Abstract
The effects of atenolol, a new beta1-blocking drug, on pulse rate, sweating, and blood glucose levels during insulin-induced hypoglycaemia were studied in a double-blind crossover trial in eight normal subjects using placebo and propranolol as reference agents. The intensity of induced hypoglycaemia was identical for atenolol, propranolol, and placebo. Propranolol prolonged hypoglycaemia, but atenolol did not. Atenolol may therefore be safe for use in patients receiving insulin.
摘要
在一项双盲交叉试验中，以安慰剂和普萘洛尔作为对照药物，对8名正常受试者研究了新型β1受体阻滞剂阿替洛尔在胰岛素诱导低血糖期间对脉搏率、出汗及血糖水平的影响。阿替洛尔、普萘洛尔及安慰剂诱导的低血糖强度相同。普萘洛尔可延长低血糖持续时间，但阿替洛尔不会。因此，阿替洛尔对接受胰岛素治疗的患者可能是安全的。
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