van Rooy E M, Sagerman R H
Division of Radiation Oncology, State University of New York Health Science Center, Syracuse 13210.
Radiology. 1994 Jun;191(3):857-61. doi: 10.1148/radiology.191.3.8184079.
To determine the late clinical effects of irradiation in stage I seminoma.
From 1966 to 1991, 104 patients with stage I seminoma were treated and followed up. After inguinal orchiectomy, all underwent megavoltage infradiaphragmatic irradiation through a "hockey stick" field encompassing the periaortic and ipsilateral iliac lymph nodes (30 Gy in 1.5-Gy fractions).
There were no serious, acute toxic effects or late complications. Three patients developed tumor recurrence at 9, 10, and 17 months; two had no evident disease 5 and 25 years after salvage chemotherapy and radiation therapy. Six patients developed second malignancies a mean of 10 years after treatment. None were considered to be radiation induced, and five of these patients had no evident disease after appropriate treatment.
The first course of postorchiectomy irradiation controls stage I seminoma in most patients (101 of 104 [97.1%]) and causes no serious, acute toxic effects or late complications.
确定I期精原细胞瘤放疗的晚期临床效果。
1966年至1991年，对104例I期精原细胞瘤患者进行治疗并随访。腹股沟睾丸切除术后，所有患者均通过“曲棍球棒”野接受膈下兆伏放疗，该野包括腹主动脉旁和同侧髂淋巴结（30 Gy，每次1.5 Gy）。
无严重急性毒性反应或晚期并发症。3例患者分别在9个月、10个月和17个月出现肿瘤复发；2例患者在挽救性化疗和放疗后5年和25年无明显疾病。6例患者在治疗后平均10年发生第二原发恶性肿瘤。均不认为是放疗所致，其中5例患者经适当治疗后无明显疾病。
睾丸切除术后首次放疗可控制大多数患者（104例中的101例[97.1%]）的I期精原细胞瘤，且无严重急性毒性反应或晚期并发症。
