Filer W D, Filer R B
Department of Family Medicine at York (Pa.) Hospital.
Am Fam Physician. 1994 May 15;49(7):1639-44.
Transdermal delivery of estrogen is an alternative to the oral route in patients receiving hormone replacement therapy for the prevention of osteoporosis. Both transdermal and oral regimens have been shown to be effective. They can be prescribed as either cyclical or continuous regimens. With the transdermal system, the first-pass hepatic metabolism that occurs with oral agents is avoided. However, the clinical significance of this bypass has not been determined. This delivery system offers a new option in the prevention of osteoporosis, an escalating public health problem.
对于接受激素替代疗法预防骨质疏松症的患者，经皮雌激素给药是口服途径的一种替代方法。经皮和口服给药方案均已证明有效。它们可以规定为周期性或连续性给药方案。使用经皮给药系统可避免口服制剂所发生的首过肝代谢。然而，这种绕过首过肝代谢的临床意义尚未确定。这种给药系统为预防骨质疏松症提供了一种新选择，骨质疏松症是一个日益严重的公共卫生问题。
