Spencer J M, Silvers D N, Grossman M E
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York.
Br J Dermatol. 1994 Apr;130(4):514-9. doi: 10.1111/j.1365-2133.1994.tb03389.x.
Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding drug exposure, and rapid disappearance of the eruption after the drug is stopped, suggest a drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following drug administration. The history of preceding drug exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were drug-induced.
伴有发热的泛发性脓疱疹给诊断带来挑战。既往有药物接触史，且停药后皮疹迅速消退，提示病因是药物性而非脓疱型银屑病。我们描述并评估了4例用药后出现泛发性脓疱疹患者的临床和组织学特征。这些病例既往有药物接触史，且皮损炎症浸润中存在数量不等的嗜酸性粒细胞，提示泛发性脓疱疹是药物性的。
