Kamper A M, Malbrain M, Zachee P, Chew S L
Department of Internal Medicine, Stuivenberg General Hospital, Edegem, Belgium.
Clin Rheumatol. 1994 Mar;13(1):129-31. doi: 10.1007/BF02229883.
A case of acute parvovirus B19 infection causing fever, anaemia, leukopenia, and red cell aplasia, in a patient with chronic rheumatoid arthritis is described. The patient had received low doses of corticosteroids for several years, and a small dose of methotrexate recently. There was no evidence of haemolytic anaemia, iron deficiency or drug toxicity. Recovery was associated with the development of antibodies against parvovirus B19, and clearance of viraemia as detected by the polymerase chain reaction. Possible mechanisms for the development of leukopenia are discussed, but there was no evidence for haemophagocytosis.
本文描述了一例慢性类风湿性关节炎患者感染细小病毒B19后引发发热、贫血、白细胞减少和红细胞再生障碍的病例。该患者已接受低剂量皮质类固醇治疗数年，近期还服用了小剂量甲氨蝶呤。没有证据表明存在溶血性贫血、缺铁或药物毒性。康复与抗细小病毒B19抗体的产生以及聚合酶链反应检测到的病毒血症清除有关。文中讨论了白细胞减少发生的可能机制，但没有噬血细胞现象的证据。
