Anderson M J, Higgins P G, Davis L R, Willman J S, Jones S E, Kidd I M, Pattison J R, Tyrrell D A
J Infect Dis. 1985 Aug;152(2):257-65. doi: 10.1093/infdis/152.2.257.
Healthy adult volunteers were inoculated intranasally with human parvovirus obtained from an asymptomatic blood donor. One week after inoculation, intense viremia was observed in seronegative volunteers, accompanied by a mild illness with pyrexia, malaise, myalgia, itching, and excretion of virus from the respiratory tract. In the following week hematologic studies revealed reticulocytopenia with an associated slight drop in hemoglobin concentration, lymphopenia, neutropenia, and a drop in platelet counts. At 17-18 days after inoculation a second-phase illness with rash and arthralgia lasting three to four days occurred in three of four infected volunteers. This study confirms the etiologic role of human parvovirus in erythematous rash illness, with the second-phase illness being consistent with adult cases of erythema infectiosum. Moreover, the hematologic changes associated with infection support the hypothesis that the same virus is responsible for the temporary arrest of erythropoiesis that leads to aplastic crisis in persons with chronic hemolytic anemia.
健康成年志愿者经鼻内接种从一名无症状献血者获取的人细小病毒。接种一周后，在血清阴性的志愿者中观察到强烈的病毒血症，同时伴有轻度疾病，症状包括发热、不适、肌痛、瘙痒以及呼吸道病毒排出。在接下来的一周，血液学研究显示网织红细胞减少，同时血红蛋白浓度略有下降、淋巴细胞减少、中性粒细胞减少以及血小板计数下降。接种后17 - 18天，四名受感染志愿者中有三名出现了持续三到四天的伴有皮疹和关节痛的第二阶段疾病。这项研究证实了人细小病毒在红斑疹疾病中的病因学作用，第二阶段疾病与传染性红斑的成人病例一致。此外，与感染相关的血液学变化支持了这样一种假说，即同一病毒导致慢性溶血性贫血患者红细胞生成暂时停止从而引发再生障碍危象。
