Han J S, Chen X H, Yuan Y, Yan S C
Neuroscience Research Center, Beijing Medical University.
Chin Med J (Engl). 1994 Jan;107(1):6-11.
Thirty-two patients with spinally originated muscle spasticity were treated with a transcutaneous electrical nerve stimulator, the Han's acupoint nerve stimulator (HANS) via skin electrodes placed over the acupoints on the hand and leg. High frequency (100 Hz), but not the low frequency (2 Hz), stimulation was effective in ameliorating muscle spasticity. While the therapeutic effect lasted for only 10 minutes in the first treatment, it became consolidated after consecutive daily treatment for 3 months. The anti-spastic effect induced by high frequency electrical stimulation can be partially reversed by a high dose of naloxone. The results suggest that the anti-spastic effect elicited by peripheral electrical stimulation is mediated, at least in part, by the endogenous opioid ligand interacting with the kappa opiate receptors, most probably dynorphin, in the central nervous system.
32例脊髓源性肌肉痉挛患者接受经皮神经电刺激治疗，即通过置于手部和腿部穴位上的皮肤电极使用韩氏穴位神经刺激仪（HANS）。高频（100Hz）而非低频（2Hz）刺激对改善肌肉痉挛有效。首次治疗时治疗效果仅持续10分钟，但连续每日治疗3个月后效果巩固。高剂量纳洛酮可部分逆转高频电刺激诱导的抗痉挛作用。结果表明，外周电刺激引发的抗痉挛作用至少部分是由内源性阿片样物质配体与中枢神经系统中的κ阿片受体相互作用介导的，最有可能是强啡肽。
