Dewailly E, Ryan J J, Laliberté C, Bruneau S, Weber J P, Gingras S, Carrier G
Community Health Department, CHUL, Québec, Canada.
Environ Health Perspect. 1994 Jan;102 Suppl 1(Suppl 1):205-9. doi: 10.1289/ehp.94102s1205.
Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychlorodibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (PCBs) including non-ortho, mono-ortho, and di-ortho congeners. Total 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEqs) for PCBs were 3.5 times higher in Inuit milk samples than in 96 Caucasian milk samples. Among the 185 fishermen from the Lower North Shore of the Gulf of the St. Lawrence River, we evaluated 10 highly exposed fishermen for their coplanar PCB blood levels. Total TEqs were 900 ng/kg for highly exposed individuals with 36 ng/kg for controls. In these two nonoccupationally exposed populations, coplanar PCBs make a larger contribution to the TEq than PCDDs and PCDFs. However, the mono-ortho penta CB No. 118 is the major contributor for the total toxicity.
1989 - 1990年对两个偏远沿海人群的有机氯生物暴露情况进行了评估。由于这两个人群大量摄入海产品，其体内的生物含量很高。对来自魁北克北极地区因纽特妇女的109份母乳样本进行了分析，以确定多氯二苯并对二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）以及包括非邻位、单邻位和双邻位同系物在内的共平面多氯联苯（PCBs）的含量水平。因纽特母乳样本中多氯联苯的总2,3,7,8 - 四氯二苯并对二恶英当量（TEqs）比96份高加索母乳样本中的高3.5倍。在圣劳伦斯河湾北岸的185名渔民中，我们评估了10名高暴露渔民的共平面多氯联苯血液含量水平。高暴露个体的总TEqs为900纳克/千克，对照个体为36纳克/千克。在这两个非职业暴露人群中，共平面多氯联苯对TEq的贡献比多氯二苯并对二恶英和多氯二苯并呋喃更大。然而，单邻位五氯联苯118是总毒性的主要贡献者。
