抗癌药物的有限采样模型。
Limited-sampling models for anticancer agents.
作者信息
van Warmerdam L J, ten Bokkel Huinink W W, Maes R A, Beijnen J H
机构信息
Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
出版信息
J Cancer Res Clin Oncol. 1994;120(7):427-33. doi: 10.1007/BF01240143.
Abstract
Pharmacokinetic parameters of antineoplastic drugs are usually generated from concentration/time profiles obtained after multiple venipunctures. With limited-sampling models (LSM) this number can be reduced to between one and three timed plasma samples. LSMs may facilitate population pharmacokinetic/pharmacodynamic studies, which eventually may lead to a dosing strategy based on the characteristics of the individual patient. In this article, the development, validation and application of several LSMs reported in the literature are reviewed.
摘要
抗肿瘤药物的药代动力学参数通常由多次静脉穿刺后获得的浓度/时间曲线生成。使用有限采样模型（LSM），这个数量可以减少到一到三个定时采集的血浆样本。LSM可能有助于群体药代动力学/药效学研究，最终可能会形成基于个体患者特征的给药策略。在本文中，对文献中报道的几种LSM的开发、验证和应用进行了综述。
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