Pascual-Leone A, Valls-Solé J, Brasil-Neto J P, Cammarota A, Grafman J, Hallett M
Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Neurology. 1994 May;44(5):892-8. doi: 10.1212/wnl.44.5.892.
We studied the effects of repetitive transcranial stimulation of the motor cortex (rTMS) on choice reaction time (cRT), movement time (MT), and error rate (ER) in a serial reaction-time task in six medicated patients with Parkinson's disease (PD) and 10 age-matched normal controls. In normal subjects, subthreshold 5-Hz rTMS did not significantly change cRT, slightly shortened MT, but increased ER. In the patients, rTMS significantly shortened cRT and MT without affecting ER. These effects did not impair procedural learning. Performance on a grooved peg-board test was improved by rTMS in the same PD patients, especially when they were off medications, but worsened in the normal subjects. Repetitive, subthreshold motor cortex stimulation can improve performance in patients with PD and could be useful therapeutically.
我们研究了重复经颅磁刺激运动皮层（rTMS）对6名接受药物治疗的帕金森病（PD）患者和10名年龄匹配的正常对照者在序列反应时任务中的选择反应时（cRT）、运动时间（MT）和错误率（ER）的影响。在正常受试者中，阈下5赫兹rTMS并未显著改变cRT，轻微缩短了MT，但增加了ER。在患者中，rTMS显著缩短了cRT和MT，而不影响ER。这些效应并未损害程序性学习。同样是这些PD患者，rTMS改善了他们在凹槽钉板测试中的表现，尤其是在他们未服药时，但在正常受试者中却使表现变差。重复阈下运动皮层刺激可改善PD患者的表现，可能具有治疗作用。
