Campo M S, Jarrett W F, O'Neil W, Barron R J
Beatson Institute for Cancer Research, CRC Beatson Laboratories, University of Glasgow.
Res Vet Sci. 1994 Mar;56(2):151-7. doi: 10.1016/0034-5288(94)90097-3.
During a long term experiment designed to identify the contribution of bovine papillomavirus type 4 (BPV-4), environmental mutagens and immunosuppressants to the development of carcinomas of the upper alimentary tract of cattle, there was evidence of latent papillomavirus infection. Papillomatosis-free animals, when immunosuppressed either by feeding bracken fern or by azathioprine treatment, developed skin warts containing either BPV-1 or BPV-2. Skin warts appeared also in an immunocompetent animal at sites of damaged skin. It was concluded that the animals harboured latent papillomavirus which was reactivated by immunosuppression and/or physical trauma, causing skin warts. Papillomavirus DNA was also detected in lymphocytes of both experimental and control animals, suggesting that one of the sites of latency may be the circulating lymphocyte.
在一项旨在确定牛乳头瘤病毒4型（BPV-4）、环境诱变剂和免疫抑制剂对牛上消化道癌发展的影响的长期实验中，有潜伏乳头瘤病毒感染的证据。未患乳头瘤病的动物，通过喂食蕨菜或硫唑嘌呤治疗进行免疫抑制后，会出现含有BPV-1或BPV-2的皮肤疣。在一只免疫功能正常的动物的受损皮肤部位也出现了皮肤疣。得出的结论是，这些动物携带潜伏乳头瘤病毒，该病毒通过免疫抑制和/或物理创伤被重新激活，从而导致皮肤疣。在实验动物和对照动物的淋巴细胞中也检测到了乳头瘤病毒DNA，这表明潜伏部位之一可能是循环淋巴细胞。
