健康母马及其幼驹的胎盘和血液中牛乳头瘤病毒DNA的分子检测
Molecular Detection of Bovine Papillomavirus DNA in the Placenta and Blood of Healthy Mares and Respective Foals.
作者信息
Savini Federica, Gallina Laura, Mazza Francesca, Mariella Jole, Castagnetti Carolina, Scagliarini Alessandra
机构信息
Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra, 50 Ozzano Emilia, Bologna 40064, Italy.
出版信息
Vet Sci. 2019 Feb 6;6(1):14. doi: 10.3390/vetsci6010014.
Abstract
Despite the characteristic species specificity of Papillomaviruses (PVs), the bovine papillomavirus (BPV) types 1, 2, and-more rarely-13, can cross-infect equids, where they are involved in the pathogenesis of sarcoid neoplasms. Sarcoids are locally invasive fibroblastic skin tumors that represent the most common skin neoplasms in horses worldwide. The transmission mechanism of BPV is still controversial in horses. Thus far, direct and indirect routes have been implicated, while vertical transmission has been suggested after the detection of viral DNA in the semen of healthy stallions. Testing of the blood and placenta of non-sarcoid baring mares and their respective foals revealed that the equine placenta can harbor BPV DNA, leading us to speculate a possible prenatal vertical DNA transmission in equids.
摘要
尽管乳头瘤病毒（PVs）具有特征性的物种特异性，但1型、2型以及更罕见的13型牛乳头瘤病毒（BPV）可交叉感染马科动物，并参与肉瘤样肿瘤的发病机制。肉瘤样瘤是局部侵袭性成纤维细胞性皮肤肿瘤，是全球马匹中最常见的皮肤肿瘤。BPV在马中的传播机制仍存在争议。到目前为止，已经涉及直接和间接途径，而在健康种马的精液中检测到病毒DNA后，有人提出了垂直传播。对未患肉瘤样瘤的母马及其各自幼驹的血液和胎盘进行检测发现，马胎盘可携带BPV DNA，这使我们推测马科动物可能存在产前垂直DNA传播。
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