Johnsson H, Niklasson P M
J Clin Pathol. 1976 May;29(5):438-40. doi: 10.1136/jcp.29.5.438.
Highly purified capsular polysaccharides from groups A, B, and C meningococci and from two strains of Escherichia coli did not aggregate human or dog platelets in vitro. Nor was there any detectable effect on platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, or collagen. The results do not support the hypothesis that capsular polysaccharides are involved in the pathogenesis of thrombocytopenia often seen in severe infections with these bacteria.
来自A、B和C群脑膜炎球菌以及两株大肠杆菌的高度纯化荚膜多糖,在体外不会使人类或犬类血小板聚集。对于由二磷酸腺苷(ADP)、肾上腺素或胶原蛋白诱导的血小板聚集,也未检测到任何影响。这些结果并不支持以下假说:荚膜多糖参与了这些细菌严重感染时常见的血小板减少症的发病机制。