McWalter G M, el-Kafrawy A H, Mitchell D F
J Am Dent Assoc. 1976 Jul;93(1):105-10. doi: 10.14219/jada.archive.1976.0587.
The pulps of 40 permanent teeth of two monkeys were mechanically exposed and contaminated with adjacent saliva or plaque for 3 to 5 1/2 hours. The pulps were then capped with either Keflin (an antibiotic), Durelon (a polycarboxylate cement), or Dycal (a calcium hydroxide compound). Varnish and then amalgam were inserted. Each monkey received at least one dose of Procion red H-8BS vital dye. The teeth were extracted from one monkey 23 months after capping and from the other monkey 29 months after capping. Serial, decalcified, 7 mum-thick paraffin sections were prepared. Alternate slides were stained with hematoxylin ane eosin. Unstained sections were examined for Procion labeling, and selected slides were stained by the Brown-Brenn method for bacteria. Of 13 teeth capped with Keflin, only 4 responded satisfactorily. All of the Dycal and Durelon-capped pulps were successful at both time intervals. All of the Dycal-capped pulps showed complete bridging and no inflammation or pulp obliteration. Bridging was complete in only three of the Durelon-capped pulps. The findings of this study support the findings in our previous study3 and further substantiate the effectiveness of Dycal as a pulp-capping agent. The often-repeated claim that calcium hydroxide compounds exert a persistent stimulating effect on the pulp resulting in its eventual obliteration was not supported. Durelon is not recommended for pulp capping since the material apparently lacks an antibacterial effect and does not stimulate reparative dentinogenesis at the exposure site. The low rate of satisfactory responses of pulps capped with Keflin, as used, precludes its use of pulp capping.
将两只猴子的40颗恒牙牙髓进行机械暴露，并用相邻的唾液或牙菌斑污染3至5个半小时。然后用凯夫林（一种抗生素）、杜雷纶（一种聚羧酸锌水门汀）或Dycal（一种氢氧化钙化合物）覆盖牙髓。接着涂上清漆，再填入汞合金。每只猴子至少接受一剂普施安红H - 8BS活性染料。在覆盖牙髓23个月后从一只猴子身上拔牙，29个月后从另一只猴子身上拔牙。制备连续的、脱钙的、7微米厚的石蜡切片。交替的玻片用苏木精和伊红染色。未染色的切片检查普施安标记，选择的玻片用布朗-布伦染色法检测细菌。在13颗用凯夫林覆盖的牙齿中，只有4颗反应令人满意。在两个时间间隔内，所有用Dycal和杜雷纶覆盖的牙髓均成功。所有用Dycal覆盖的牙髓均显示完全桥接，无炎症或牙髓闭锁。用杜雷纶覆盖的牙髓中只有三颗完全桥接。本研究结果支持我们之前研究3的结果，并进一步证实了Dycal作为牙髓盖髓剂的有效性。经常有人声称氢氧化钙化合物对牙髓有持续的刺激作用，最终导致牙髓闭锁，但该说法未得到支持。不推荐使用杜雷纶进行牙髓盖髓，因为该材料显然缺乏抗菌作用，且不能在暴露部位刺激修复性牙本质形成。按照使用方法，用凯夫林覆盖的牙髓令人满意的反应率较低，因此不适合用于牙髓盖髓。
