Wang X, Guyer B, Paige D M
Department of Maternal and Child Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD.
Int J Epidemiol. 1994 Feb;23(1):119-28. doi: 10.1093/ije/23.1.119.
This study investigated racial differences in gestational age-specific birthweight in a sample of 21,288 Chinese, 11,882 Japanese and 65,818 White resident singleton livebirths, obtained from the National Center for Health Statistics 1983 and 1984 linked birth/infant death cohort files. The gestational age-specific birthweight distributions of Chinese and Japanese were similar, but differed from those of Whites both in the mean level and in the variance. The mean birth-weights of Chinese and Japanese as compared to that of White infants were 4-5% lower among preterm births, and 5-6% lower among term births, after adjustment was made for gestational age, demographic variables, use of antenatal care and infant gender. The racial differences in gestational age-specific birthweight were even greater at the 90th percentile but smaller at the 10th percentile. These racial differences should be considered in both clinical evaluation of newborns and in epidemiological studies. Significant interactions were found between race and such maternal variables as education, marital status, birthplace, and month during which antenatal care began. It suggests that recognition of racial differences in risk factors and exposure-response relationships may be valuable in specifying interventions for intrauterine growth retardation among different racial groups.
本研究调查了21288名华裔、11882名日裔和65818名白人常住单胎活产婴儿样本中特定孕周出生体重的种族差异,这些数据来自美国国家卫生统计中心1983年和1984年的出生/婴儿死亡队列关联档案。华裔和日裔特定孕周出生体重分布相似,但在平均水平和方差方面均与白人不同。在对孕周、人口统计学变量、产前护理使用情况和婴儿性别进行调整后,与白人婴儿相比,华裔和日裔早产婴儿的平均出生体重低4 - 5%,足月儿低5 - 6%。特定孕周出生体重的种族差异在第90百分位数时更大,在第10百分位数时更小。在新生儿临床评估和流行病学研究中都应考虑这些种族差异。研究发现种族与母亲的教育程度、婚姻状况、出生地以及开始产前护理的月份等变量之间存在显著交互作用。这表明认识到不同种族群体在危险因素和暴露-反应关系方面的差异,对于制定针对宫内生长迟缓的干预措施可能具有重要价值。