Thomason J M, Seymour R A, Rice N
Department of Prosthodontics, University of Newcastle upon Tyne, UK.
J Clin Periodontol. 1993 Jan;20(1):37-40. doi: 10.1111/j.1600-051x.1993.tb01757.x.
The gingival health of 32 renal transplant patients who were medicated with cyclosporin was compared with a similar cohort of 23 renal transplant patients medicated with both cyclosporin and nifedipine. Both groups of patients had been taking the above medication for at least 3 months. Plaque scores, gingival inflammation and probing depths were similar for both groups. Patients medicated with the combination of nifedipine and cyclosporin had a significantly higher gingival overgrowth score (p = 0.046) when compared with the group receiving cyclosporin alone. The incidence of clinically significant overgrowth (i.e., overgrowth > 30% which would require surgical intervention) was similar in both groups. Gingival overgrowth was not related to cyclosporin dosage. It is concluded that patients taking cyclosporin or cyclosporin and nifedipine experience gingival overgrowth and that the severity of the overgrowth is greater in patients taking the combined therapy. The levels of plaque and gingival inflammation appear to be associated with this phenomenon.
将32名接受环孢素治疗的肾移植患者的牙龈健康状况与23名同时接受环孢素和硝苯地平治疗的肾移植患者组成的类似队列进行了比较。两组患者服用上述药物均至少3个月。两组患者的菌斑评分、牙龈炎症和探诊深度相似。与仅接受环孢素治疗的组相比，接受硝苯地平和环孢素联合治疗的患者牙龈增生评分显著更高（p = 0.046）。两组临床上显著增生（即增生> 30%，需要手术干预）的发生率相似。牙龈增生与环孢素剂量无关。得出的结论是，服用环孢素或环孢素与硝苯地平的患者会出现牙龈增生，联合治疗患者的增生严重程度更大。菌斑和牙龈炎症水平似乎与这一现象有关。
