Hicks J T, Albrecht P
J Infect Dis. 1976 Jun;133(6):648-54. doi: 10.1093/infdis/133.6.648.
Infection of rhesus monkeys with measles virus induced specific complement-dependent cytolytic antibodies during the early phase of acute infection. The development of maximal levels of the complement-dependent cytolytic antibodies appears to be dependent on the respiratory rather than the parenteral route of infection and on the use of live rather than killed measles virus. These levels of cytolytic antibodies seem to be independent of levels of simultaneously developing neutralizing and hemagglutinating antibodies. It is proposed that complement-dependent cytolytic antibodies play an important role in the elimination of acute measles virus in vivo by lysing the foci of infected cells and by blocking the spread of virus by cell fusion.
在急性感染的早期阶段，用麻疹病毒感染恒河猴可诱导产生特异性补体依赖的溶细胞抗体。补体依赖的溶细胞抗体最高水平的出现似乎取决于呼吸道而非肠道感染途径，以及使用活的而非灭活的麻疹病毒。这些溶细胞抗体水平似乎与同时产生的中和抗体和血凝抗体水平无关。有人提出，补体依赖的溶细胞抗体通过裂解受感染细胞灶以及通过阻止病毒通过细胞融合传播，在体内消除急性麻疹病毒中起重要作用。
