Buynak E B, Roehm R R, Tytell A A, Bertland A U, Lampson G P, Hilleman M R
JAMA. 1976 Jun 28;235(26):2832-4.
A highly purified and inactivated vaccine was made of hepatitis B virus surface antigen. The vaccine was tested exhaustively for safety by ordinary procedures and additionally in chimpanzees and marmosets. It was highly potent and induced antibody in guinea pigs, grivet monkeys, and chimpanzees after three doses of vaccine were given subcutaneously. Chimpanzees given three doses of vaccine were protected against challenge with 1,000 chimpanzee-infectious doses of live human hepatitis B virus given intravenously in controlled studies. Tests of the vaccine for control of hepatitis B in man are to be carried out.
一种由乙肝病毒表面抗原制成的高度纯化的灭活疫苗。该疫苗通过常规程序进行了全面的安全性测试，此外还在黑猩猩和狨猴身上进行了测试。它效力很高，在豚鼠、灰绿猴和黑猩猩皮下接种三剂疫苗后能诱导产生抗体。在对照研究中，给黑猩猩接种三剂疫苗后，它们能抵御静脉注射1000个黑猩猩感染剂量的人类乙肝活病毒的攻击。将对该疫苗用于人类控制乙肝的情况进行测试。
