Genito Christopher J, Batty Cole J, Bachelder Eric M, Ainslie Kristy M
Department of Microbiology and Immunology University of North Carolina at Chapel Hill 4211 Marsico Hall, 125 Mason Farm Road Chapel Hill NC 27599 USA.
Division of Pharma Engineering & Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill 4211 Marsico Hall, 125 Mason Farm Road Chapel Hill NC 27599 USA.
Adv Nanobiomed Res. 2021 Mar;1(3):2000041. doi: 10.1002/anbr.202000041. Epub 2021 Jan 18.
Vaccines have advanced human health for centuries. To improve upon the efficacy of subunit vaccines they have been formulated into nano/microparticles for infectious diseases. Much progress in the field of polymeric particles for vaccine formulation has been made since the push for a tetanus vaccine in the 1990s. Modulation of particle properties such as size, surface charge, degradation rate, and the co-delivery of antigen and adjuvant has been used. This review focuses on advances in the understanding of how these properties influence immune responses to injectable polymeric particle vaccines. Consideration is also given to how endotoxin, route of administration, and other factors influence conclusions that can be made. Current manufacturing techniques involved in preserving vaccine efficacy and scale-up are discussed, as well as those for progressing polymeric particle vaccines toward commercialization. Consideration of all these factors should aid the continued development of efficacious and marketable polymeric particle vaccines.
几个世纪以来，疫苗一直在推动人类健康的进步。为了提高亚单位疫苗的效力，人们已将其制成用于传染病的纳米/微粒。自20世纪90年代推动破伤风疫苗研发以来，疫苗制剂领域的聚合物微粒取得了很大进展。人们已采用调节颗粒性质的方法，如大小、表面电荷、降解速率以及抗原和佐剂的共同递送。本综述重点关注在理解这些性质如何影响对可注射聚合物微粒疫苗的免疫反应方面取得的进展。同时还考虑了内毒素、给药途径和其他因素如何影响所得出的结论。文中讨论了目前在保持疫苗效力和扩大规模方面所涉及的制造技术，以及推动聚合物微粒疫苗商业化的技术。考虑到所有这些因素应有助于持续开发有效且适销的聚合物微粒疫苗。
