Johanson C E, Kandel D A, Bonese K
Pharmacol Biochem Behav. 1976 Apr;4(4):427-33. doi: 10.1016/0091-3057(76)90059-9.
In Experiment 1.6 rhesus monkeys prepared with intravenous catheters responded on a fixed-ratio 10 schedule for either an injection of 0.2 mg/kg of cocaine or 0.5 mg/kg of pentobarbital during a daily 3 hr session. The substitution of saline or various doses of perphenazine resulted in very low rates of responding. These results indicate that perphenazine is not a positive reinforcer. Pretreating animals maintained on 0.1 mg/kg or 0.2 mg/kg of cocaine with perphenazine resulted in increases in rate of self-administration at some doses and a decrease in rate at higher doses. The dose of perphenazine which resulted in the maximal increase in cocaine self-administration was directly related to the dose of cocaine maintaining responding. Pretreating animals maintained on 0.5 mg/kg of pentobarbital with perphenazine had no effect at doses which increased cocaine self-administration but decreased rate of pentobarbital self-administration at higher doses. These results indicate that perphenazine is capable of antagonizing some of the effects of cocaine.
在实验1.6中，通过静脉导管准备好的恒河猴在每天3小时的实验时段内，按照固定比率10的时间表进行反应，以获取0.2毫克/千克可卡因或0.5毫克/千克戊巴比妥的注射。用生理盐水或不同剂量的奋乃静替代后，反应率非常低。这些结果表明奋乃静不是一种阳性强化物。用奋乃静对维持在0.1毫克/千克或0.2毫克/千克可卡因剂量下的动物进行预处理，在某些剂量下会导致自我给药率增加，而在较高剂量下会导致自我给药率降低。导致可卡因自我给药最大增加的奋乃静剂量与维持反应的可卡因剂量直接相关。用奋乃静对维持在0.5毫克/千克戊巴比妥剂量下的动物进行预处理，在增加可卡因自我给药的剂量下没有效果，但在较高剂量下会降低戊巴比妥自我给药率。这些结果表明奋乃静能够拮抗可卡因的一些作用。
