Esser C
Medical Institute for Environmental Hygiene, Düsseldorf, Germany.
Int Arch Allergy Immunol. 1994;104(2):126-30. doi: 10.1159/000236719.
2,3,7,8-Tetrachlorodibenzo-p-dioxin, or simply 'dioxin', is an environmental pollutant, infamous for its extremely high toxicity. Dioxin mimics the unknown natural ligand of the cytosolic arylhydrocarbon receptor which is conspicuously abundant in the thymus, and acts as a transcription factor upon ligand engagement. Thymus atrophy and immunosuppression have long been known to be major effects of dioxin exposure, evident at even very low doses. In a meeting held in Düsseldorf, FRG, the immunotoxicology of dioxin was discussed with respect to the pathomechanisms of dioxins on lymphocyte stem cells, thymus and T cells, cytokine modulation, and other components of the immune system. Such immunological insults may have consequences for the risk assessment of chemical compounds like dioxin.
2,3,7,8-四氯二苯并-对-二恶英，或简称为“二恶英”，是一种环境污染物，因其极高的毒性而臭名昭著。二恶英模拟细胞溶质芳烃受体的未知天然配体，该受体在胸腺中显著丰富，并在配体结合后作为转录因子发挥作用。长期以来，胸腺萎缩和免疫抑制一直被认为是二恶英暴露的主要影响，即使在非常低的剂量下也很明显。在德国杜塞尔多夫举行的一次会议上，就二恶英对淋巴细胞干细胞、胸腺和T细胞的致病机制、细胞因子调节以及免疫系统的其他组成部分，讨论了二恶英的免疫毒理学。这种免疫损伤可能会对二恶英等化合物的风险评估产生影响。
