Yap L C, Ho R T, Jawan B, Lee J H
Department of Anesthesiology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.
Acta Anaesthesiol Sin. 1994 Mar;32(1):45-50.
Magnesium sulfate may prevent increase in serum potassium produced by succinylcholine and cause transient hypotension. The present study was designed to evaluate the effect of magnesium sulfate on heart rate, blood pressure and hyperkalemic response following succinylcholine injection during tracheal intubation. Twenty patients, ASA class I-II, scheduled for elective surgery were equally and randomly allocated to two groups. Heart rate, blood pressure, venous and arterial potassium levels were measured immediately before intubation. Induction was achieved with fentanyl 2 ug/kg and thiopental 5 mg/kg i.v., and intubation was facilitated with succinylcholine 1.0 mg/kg i.v. In the magnesium group (group I), 60 mg/kg of magnesium sulfate was infused intravenously in 1-1.5 min immediately before succinylcholine injection. The control group (group II) received an equal volume of normal saline in the same way. Heart rate, blood pressure, venous and arterial potassium levels were measured at 1, 3, 5 and 10 minutes after intubation. The results showed that magnesium sulfate could attenuate the hypertensive response at 1 minute and the hyperkalemic response at 1 and 3 minutes following succinylcholine-facilitated intubation; the tachycardiac response at 1 minute after intubation could not be reduced by this agent. We concluded that bolus infusion of magnesium sulfate may be of help in reducing the hypertensive response during laryngoscopy and intubation.
硫酸镁可能会阻止琥珀酰胆碱引起的血清钾升高，并导致短暂性低血压。本研究旨在评估气管插管期间注射琥珀酰胆碱后硫酸镁对心率、血压和高钾血症反应的影响。将20例计划进行择期手术的ASA I-II级患者平均随机分为两组。在插管前立即测量心率、血压、静脉血和动脉血中的钾水平。静脉注射芬太尼2μg/kg和硫喷妥钠5mg/kg进行诱导，并静脉注射琥珀酰胆碱1.0mg/kg辅助插管。在硫酸镁组（I组），在注射琥珀酰胆碱前1-1.5分钟内静脉输注60mg/kg硫酸镁。对照组（II组）以相同方式接受等体积的生理盐水。在插管后1、3、5和10分钟测量心率、血压、静脉血和动脉血中的钾水平。结果表明，硫酸镁可减弱琥珀酰胆碱辅助插管后1分钟的高血压反应以及1和3分钟的高钾血症反应；该药物不能降低插管后1分钟的心动过速反应。我们得出结论，静脉推注硫酸镁可能有助于减轻喉镜检查和插管期间的高血压反应。
