Arienti V, Magri F, Boriani L, Maconi G, Bassein L, Baraldini M, Marzio L, Gasbarrini G
University of Bologna, Italy.
Dig Dis Sci. 1994 Jun;39(6):1309-12. doi: 10.1007/BF02093798.
To evaluate the effects of a single oral dose of erythromycin on gastric and gallbladder emptying, 10 volunteers, without a known history of gastrointestinal disease, were investigated. Erythromycin stearate (500 mg) or placebo was given on separate mornings 30 min before a standard solid meal in a randomized, double-blind, crossover study. Gastric and gallbladder emptying rates were simultaneously evaluated by means of real-time ultrasonography. Gastric antral area and gallbladder volume were determined before the meal and 30, 60, 120, 180, 240, and 300 min after commencing eating. Erythromycin, compared to placebo, significantly accelerates and increases the degree of both gastric and gallbladder emptying. As previously reported for intravenous and chronic oral assumption, also a single dose of oral erythromycin is able to accelerate gastric and gallbladder emptying in normal human subjects.
为评估单次口服红霉素对胃和胆囊排空的影响，我们对10名无胃肠道疾病史的志愿者进行了研究。在一项随机、双盲、交叉研究中，于标准固体餐进食前30分钟的不同早晨分别给予硬脂酸红霉素（500毫克）或安慰剂。通过实时超声检查同时评估胃和胆囊排空率。在进食前以及进食开始后30、60、120、180、240和300分钟测定胃窦面积和胆囊体积。与安慰剂相比，红霉素显著加速并增加胃和胆囊的排空程度。正如先前关于静脉注射和长期口服给药的报道一样，单次口服红霉素也能够加速正常受试者的胃和胆囊排空。
