Zajícek D, Páv J, Dvorák M, Danĕk J
Vet Med (Praha). 1976 Jan;21(1):35-44.
With 24 head of wild boars (Sus scrofa L.) of both sexes of the age of one to two years, kept in a game preserve and naturally infected with parasites of the species Mestastrongylus pudendotectus, M. elongatus, Ascarops strongylina, Physocephalus sexalatus, Ascaris suum, Globocephalus urosubulatus, Oesophagostomum dentatum, Trichocephalus suis, Eimeria debliecki, and E. perminuta, three experiments were performed with feeds premedicated with anthelmintics: pyrantel tartrate + diethylcarbamazine tartrate (a dose of 25 + 50 mg kg-1 of live weight), Mebendazole 5 p. c. premix and Mebendazole 50 p. c. premix (doses of 10 mg kg-1 and 40 mg kg-1 of live weight) administered for three consecutive days. According to the results of the helminthological dissections the effectiveness of pyrantel tartrate + diethylcarbamazine tartrate reached from 58.1 to 100 p. c. compared with the different species of nematodes, Mebendazole 5 p.c. premix from 47.8 to 100 p. c., and Mebendazole 50 p. c. premix reached the effectiveness of 85.4 to 100 p.c with the mentioned therapeutic doses. The results obtained from a coprological investigation showed the effectiveness, in the case of pyrantel tartrate + diethylcarbamazine tartrate, of 99.2 and 70.65 p. c. on the sixth and fifteeenth day after application, in the case of Mebendazole 5 p. c. premix 94.4 and 79.41 p. c. on the tenth and twentieth day after application, and in the case of of Mebendazole 50 p. c. premix it amounted to 96.0 and 100 p. c. on the tenth and twentieth day after application. In 22 head of wild boars of the total number of examined animals the minimum, maximum, and average values of the number of erythrocytes, leucocytes, of the hemoglobin content, of the hematocrit, MCV, MCH, MCHC, of the white blood count, of the protein total, of the fractions of albumin, alpha-, beta-, and gamma-globulin, of the activity of SGOT and SGPT, and of the metabolism of calcium, phosphorus, and magnesium were determined. The investigation was performed in the shortest possible time after the killing of the animals. In the examined values no marked deviations in 48 hours were found after the application had finished compared with the values determined in non-treated animals.
选用24头年龄为1至2岁的野生公猪和母猪,饲养在狩猎保护区内,这些野猪自然感染了耻阴后圆线虫、长后圆线虫、猪蛔状线虫、六翼泡首线虫、猪蛔虫、尿亚口线虫、有齿食道口线虫、猪鞭虫、德氏艾美耳球虫和微小艾美耳球虫等寄生虫。用预先添加驱虫剂的饲料进行了三项实验:酒石酸噻嘧啶+酒石酸二乙carbamazine(剂量为每千克活重25 + 50毫克)、5%甲苯咪唑预混剂和50%甲苯咪唑预混剂(剂量分别为每千克活重10毫克和40毫克),连续投喂三天。根据蠕虫学解剖结果,与不同种类的线虫相比,酒石酸噻嘧啶+酒石酸二乙carbamazine的有效性达到58.1%至100%,5%甲苯咪唑预混剂为47.8%至100%,50%甲苯咪唑预混剂在上述治疗剂量下的有效性达到85.4%至100%。粪便学调查结果显示,酒石酸噻嘧啶+酒石酸二乙carbamazine在用药后第六天和第十五天的有效性分别为99.2%和70.65%,5%甲苯咪唑预混剂在用药后第十天和第二十天的有效性分别为94.4%和79.41%,50%甲苯咪唑预混剂在用药后第十天和第二十天的有效性分别为96.0%和100%。在所有检查的24头野猪中,选取22头测定了红细胞、白细胞数量、血红蛋白含量、血细胞比容、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度、白细胞分类计数、总蛋白、白蛋白、α-、β-和γ-球蛋白组分、谷草转氨酶和谷丙转氨酶活性以及钙、磷和镁代谢的最小值、最大值和平均值。在动物宰杀后尽可能短的时间内进行了这项研究。与未治疗动物测定的值相比,用药结束后48小时内检查的值未发现明显偏差。