Edwards C H, Knight E M, Johnson A A, Oyemade U J, Cole O J, Nolan G, Westney O E, West W L, Laryea H, Hilliard P
Department of Nutritional Sciences, College of Allied Health Sciences, Howard University, Washington, D.C. 20059.
J Nutr. 1994 Jun;124(6 Suppl):917S-926S. doi: 10.1093/jn/124.suppl_6.917S.
This five-year prospective, observational study of urban women during their pregnancies was initiated in 1985 with the recruitment of women between the ages of 18 and 35 years in the prenatal clinics of Howard University Hospital and the District of Columbia Department of Human Services. The objective of the investigation was to characterize African American women by nutritional, biochemical, medical, sociocultural, psychological, lifestyle, and environmental parameters which could be used to formulate interventions to improve pregnancy outcomes. The women were all nulliparous, free of diabetes and abnormal hemoglobins, such as sickle cell disease, and no more than 28 weeks pregnant. During the early course of the study, it was apparent that 96% of the low income clinic patients had delivered infants of normal birth weight (> or = 2500 g), P = 0.001. Recruitment was then initiated at the District of Columbia General Hospital; women 16 and 17 years of age and at any gestational stage were included. This paper is the first in the series on African American women and their pregnancies. It will present the demographic characteristics of this regular cohort of 443 women who delivered live infants, the methodology used for biochemical, dietary, and psychosocial data sets, the mean values for infant gestational age, head circumference, body length, and birth weight from singleton births, and correlates of the mean values of biochemical variables for three trimesters of pregnancy with other biochemical parameters and those pregnancy outcomes.
这项针对城市女性孕期的为期五年的前瞻性观察研究始于1985年，研究对象为霍华德大学医院和哥伦比亚特区公共服务部产前诊所招募的18至35岁女性。该调查的目的是通过营养、生化、医学、社会文化、心理、生活方式和环境参数来描述非裔美国女性的特征，这些参数可用于制定改善妊娠结局的干预措施。这些女性均为初产妇，无糖尿病和异常血红蛋白，如镰状细胞病，且怀孕不超过28周。在研究初期，很明显96%的低收入诊所患者分娩出的婴儿出生体重正常（≥2500克），P = 0.001。随后在哥伦比亚特区综合医院开始招募；纳入了16岁和17岁以及处于任何妊娠阶段的女性。本文是关于非裔美国女性及其孕期系列研究的第一篇。它将呈现这443名分娩活婴的常规队列的人口统计学特征、用于生化、饮食和社会心理数据集的方法、单胎分娩的婴儿孕周、头围、身长和出生体重的平均值，以及妊娠三个阶段生化变量平均值与其他生化参数及妊娠结局的相关性。
