Stokes G H, Siddique I H, Williams B B
Am J Vet Res. 1976 Jun;37(6):735-6.
Crude hemolysin derived from Listeria monocytogenes, strains 9-125 and 1122-3, reduced phosphate utilization of rat brain mitochondria in a succinate system. Oxidation rates were not altered by addition of hemolysin to a concentration of 42 hemolytic units/ml, with a mitochondrial protein concentration of 2.3 mg/ml. At a mitochondrial protein concentration of 1.8 mg/ml, 42 hemolytic units/ml of hemolysin increased the inhibition of phosphate utilization and also reduced the oxygen uptake. An age differential was apparent, with mitochondria from young rats demonstrating uncoupling at a lower concentration of hemolysin.
从单核细胞增生李斯特菌9 - 125株和1122 - 3株中提取的粗制溶血素，在琥珀酸系统中降低了大鼠脑线粒体的磷酸盐利用率。当线粒体蛋白浓度为2.3 mg/ml时，添加至浓度为42个溶血单位/ml的溶血素不会改变氧化速率。当线粒体蛋白浓度为1.8 mg/ml时，42个溶血单位/ml的溶血素增加了对磷酸盐利用的抑制作用，同时也降低了氧气摄取。年龄差异明显，幼鼠的线粒体在较低浓度的溶血素作用下即出现解偶联现象。
