来自灌木柴胡的生物活性三萜皂苷。

Biologically active triterpene saponins from Bupleurum fruticosum.

作者信息

Guinea M C, Parellada J, Lacaille-Dubois M A, Wagner H

机构信息

Departmento de Farmacia y Tecnología Farmacéutica, Universidad de Alcalá de Henares, Madrid, Spain.

出版信息

Planta Med. 1994 Apr;60(2):163-7. doi: 10.1055/s-2006-959442.

DOI:10.1055/s-2006-959442

PMID:8202567

Abstract

Extracts of the root of B. fruticosum L. showed in a biological screening hemolytical activity, hepatoprotective and phagocytosis stimulating effects, and a specific inhibitory activity of leucine aminopeptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation of an hepatoprotective saikosaponin identified as buddlejasaponin IV and the new malonylbuddlejasaponin IV, determined as saikogenin F-3-O-[6-O-malonyl-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl (1-->3)]-beta-D-fucopyranoside. The structures were elucidated on the basis of the chemical and spectroscopic data.

摘要

醉鱼草（Buddleja fruticosum L.）根提取物在生物活性筛选中显示出溶血活性、保肝作用、刺激吞噬作用以及亮氨酸氨肽酶特异性抑制活性。对具有抗肝毒性活性的组分进行进一步监测，分离出一种保肝柴胡皂苷，鉴定为醉鱼草皂苷IV以及新的丙二酰醉鱼草皂苷IV，其结构确定为柴胡皂苷元F - 3 - O - [6 - O - 丙二酰基 - β - D - 吡喃葡萄糖基 - (1→2) - β - D - 吡喃葡萄糖基(1→3)] - β - D - 呋喃岩藻糖苷。基于化学和光谱数据阐明了其结构。